Case: 213

RTA-induced Medullary Nephrocalcinosis

Show  

History: 42 yo male with h/o recently diagnosed Sjögren's syndrome and flank pain
Solution: The patient has obvious medullary nephrocalcinosis on CT. The differential is broad, but includes three primary and most common etiologies; medullary sponge kidney, hyperparathyroidism, and renal tubular acidosis (Type 1, distal). RTA can be primary (hereditary), or secondary to a systemic process as in this case. Autoimmune disorders including Sjögren's syndrome and Lupus are relatively common underlying etiologies. The symptoms and findings can be reversed with treatment. As an aside, some believe that the character "Tiny Tim" in the Christmas Carol had Type 1 RTA. This would explain his symptoms and response to therapy.

Questions

Of the following possible etiologies, which is most likely?
  • Medullary sponge kidney
  • Oxalosis
  • Milk-alkali syndrome
  • Renal tubular acidosis
  • Hyperparathyroidism
  • Renal tuberculosis
With appropriate treatment, this can be reversible.
True
Which etiology for this finding is often associated with massive, dense calcification?
RTA, type 1.