History: 3 yo female with history of mono-like illness and persistently enlarged spleen.
Solution: Of the primary hepatic tumors of children, hepatoblastoma is the most common. It usually presents in children less than 5 years old and most frequently in children less than 2. It is more common in males and has no association with liver disease. It can produce HCG and cause precocious puberty in males and other symptoms. In addition, AFP is often elevated. If resectable and no evidence of metastatic disease, then the prognosis is pretty good. The differential includes HCC, usually in older kids (5-15) and in patients with underlying liver disease, fibrolamellar HCC, Rhabdomyosarcoma, hemangioendothelioma (usually younger patients, most common liver tumor less than 6 months), undifferentiated embyronal cell sarcoma and metastatic lesions.