A facility designed for the production of radiopharmaceuticals for preclinical and clinical research
Mission
The University of Wisconsin Radiopharmaceutical Production Facility (RPF) is situated within the Wisconsin Institutes of Medical Research, located at the University of Wisconsin School of Medicine and Public Health. The RPF houses a manufacturing area designed for the cGMP production of radiopharmaceutical agents for translational clinical research and human clinical use. This facility is staffed by experienced radiochemists and nuclear pharmacists, responsible for ensuring that the manufactured radiopharmaceuticals are cGMP compliant..
About the Facility
The University of Wisconsin Radiopharmaceutical Production Facility (RPF) is situated within the Wisconsin Institutes of Medical Research, located at the University of Wisconsin School of Medicine and Public Health. It houses a new manufacturing area designed for the production of cGMP radiopharmaceuticals. This area is equipped with multiple hot cells and synthesis modules and includes multiple quality control instruments to accommodate segregation of clinical and preclinical production activities. Additionally, a dispensing area designed in compliance with USP <797> has the capability to compound and distribute radiopharmaceuticals.
Services and Interests
- PET radiopharmaceutical production and imaging to support human clinical studies
- Production of literature PET (small molecule and biologics) and radiotherapy agents
- Preclinical and clinical development of novel PET imaging and therapeutic agents
- Production of 18F, 11C, 13N-ammonia, and 68Ga PET radiopharmaceuticals
- On-site availability of 89Zr and 64Cu radioisotopes for research
- Request Radiopharmaceutical Assessment and Development
Nuclear Pharmacy
- Shielded fume hoods for custom compounding
- Laminar Flow hoods
- Designed for USP <797> compliance
- Dispensing area for distribution
Manufacturing
- Multiple Bq and Sv Production Hot Cells
- Custom-Made Hot Cells
- Multiple Synthesis Modules
- Laminar Flow Hood
- 68Ga Generator
Quality Control
- Gas Chromatographs
- HPLC Units
- Multi-Channel Analyzers
- Dose Calibrators
- TLC Scanner
- Biological Safety Cabinets
- Incubators
Molecular Imaging
The molecular imaging research program at the University of Wisconsin (UW) is composed of a multi-disciplinary team including researchers, physicians, radiopharmaceutical production staff, technologists, supporting staff, and graduate students. The primary focus of the program is to develop new molecular imaging agents, translate new molecular imaging agents into the clinic, and discover new applications of…
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