Calibration-free Device Sizing Using Inverse Geometry X-ray Fluoroscopy

The PI of this project was:

This project was funded by: NIH

The term of this project was: February 2012 to December 2013

The number of subjects scanned during this project was: 10

Conventional quantitative coronary angiography (QCA) can be used to measure coronary blood vessels for sizing interventional devices, but it is not frequently used because of the time required for calibration and finding non-foreshortening views. The Scanning Beam Digital X-ray (SBDX) is an inverse geometry x-ray fluoroscopy system that creates real-time tomosynthetic images instead of typical x-ray projections. We have developed a novel method for measuring coronary vessels that uses SBDX images to determine diameter, length, and 3D position without calibration or optimal views. Coronary computer tomography angiography (CCTA) is a non-invasive method for accurately imaging coronary vessel structure. We will use CCTA as the gold standard to validate the length measurements and 3D structure produced by our novel method in addition to intra-vascular ultrasound (IVUS) imaging, which serves as the gold standard for vessel diameter measurements.