Comparison of Quantitative Perfusion Methods (PerfQuant II Study)

The PI of this project was:

This project was funded by: Radiology RD

The term of this project was: May 2013 to August 2013

The number of subjects scanned during this project was: 10

Absolute quantification of pulmonary perfusion using T1-weighted contrast-enhancement MRI is difficult. The difficulty fundamentally arises from the nonlinear dependence of signal intensity on contrast agent concentration in MRI. Three methods have been proposed in the literature to account for this nonlinearity by either adjusting the dose injection protocol or by post-processing. However, these methods have not yet been compared to each other. Furthermore, gadopentetate dimeglumine (Magnevist) has been the contrast agent of choice for reported literature values. But here at UW, gadobenate dimeglumine (MultiHance) is a popular contrast agent in the clinic as it is known to produce higher signal in images. In this study, we want to determine the best method to correct for the nonlinear dependencies and to show that hemodyanmic values calculated are comparable between MultiHance and Magnevist.