(GEVenc) Optimization of Venc Settings for Detection of Gastroesophageal Varices

The PI of this project is:

This project is funded by: NIH

The term of this project is: May 2022 to December 2024

The number of subjects scanned during this project is: 21

The purpose of this study is to evaluate to evaluate the optimized 4D flow methods to detect gastroesophageal varices (GEV) at risk for bleeding. This study will include 21 subjects (7 healthy volunteers, 7 patients with small, low-risk, and 7 with large, high-risk GEV). After ferumoxytol administration, each subject will undergo MRI exam of up to 1 hour including a contrast enhanced MRA and three 12-minute 4D flow MRI scans with different settings for the velocity encoding factor (Venc). The study team will evaluate the tradeoff between improved sensitivity at low vs high Venc settings to optimize the ability to (1) visualize relevant anatomy and (2) make robust flow measurements.