The specific objective of this proposed work is to evaluate safety of the engraftment of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) after injection into an immunosuppressed primate diseased right ventricle (banded pulmonary artery).
The goals of the study are to determine whether human stem cells will successfully integrate into the cardiac tissue and whether cardiac function after pulmonary artery banding improves with the stem cell treatment.
Cardiac status will be evaluated using echocardiography, loop recorder analysis, and bloodwork according to the attached timeline/figure.