Measurement of Acute Inflammation from Focal Seizures

The PI of this project was:

This project was funded by: start-up funds

The term of this project was: June 2018 to March 2020

The number of subjects scanned during this project was: 25

This study further investigates the relationship between inflammation and epilepsy by assessing whether seizures increase inflammation by performing serial PET/MR. Patients with temporal lobe epilepsy admitted to the EMU for work-up for epilepsy surgery will be recruited to the study. Patients are taken off medications to induce seizures to aid in epilepsy localization. We will obtain a PET/ MR scan at time of admission and then at time of discharge thus enabling us to find if seizures during admission induced an increase in inflammation. Clarifying if seizures induce inflammation in temporal lobe epilepsy has several important scientific and clinical implications for future treatments.