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Weibo Cai Has Two Patents Issued in Span of a Few Months

Professor Weibo Cai, PhD was part of two teams that were issued patents recently. The first patent, issued in April, is for treating acute kidney injury with DNA origami nanostructures, which can exhibit preferential renal uptake after intravenous injection. The DNA origami nanostructure includes a scaffold strand (a circular single-stranded DNA of 7249-nucleotides) and a plurality of staple strands, each of which has a length of about 20 to 60 bases. There are eight inventors listed on the patent from four research groups in four institutions. The related manuscript was published in 2018 in Nature Biomedical Engineering (PMCID: PMC6258029). The second patent, a self-powered, auto-responsive implanted vagal nerve stimulator for weight control, was issued in June. The device has a "passive" generating power source in that it harvests the stomach's movements to transform kinetic energy to electrical charge without the need for a battery. The invention is self-powering and is automatically timed to stomach peristalsis. While sporadic stimulation to the vagal nerve would seem too infrequent to cause weight loss effects, electrical stimulation delivered at the optimal time (e.g., during food consumption) has been found to optimize the effects of vagal nerve stimulation, giving the user's brain a "full stomach" signal before the user overconsumes food. Effective weight control was achieved in various animal models. The related manuscript was published in 2018 in Nature Communications. Dr. Cai was thrilled that both patents were issued. “Since I started as a faculty in 2008 at UW-Madison, I have disclosed a number of inventions to WARF. However, most of them were not accepted or filed due to various reasons. It is very exciting to have two patents issued within a few weeks. I am sure there will be many more inventions to be disclosed and issued in the next several years, and we are working very actively on some of these at the moment,” he says.

Blankenbaker and Davis Publish New Edition of Textbook

Professor Donna Blankenbaker, MD, FACR and Professor Kirkland Davis, MD, FACR recently published their latest textbook, Diagnostic Imaging: Musculoskeletal Trauma, 3^rd Edition. The book focuses largely on musculoskeletal (MSK) trauma, injuries, and sports medicine, and includes essential clinical information and information about findings one should expect using all relevant imaging modalities. This is the second edition of the book that Drs. Blankenbaker and Davis have worked on together. “We were excited about the success of our prior edition, and with MSK imaging constantly changing, an update was needed,” says Dr. Blankenbaker. The new text includes eight brand new chapters and updates to all pre-existing chapters by experts. The ultrasound component was expanded in appropriate chapters, as MSK ultrasound evolves rapidly. New high-quality illustrations and radiologic images were added to aide in the learning process. The book is available in a print and online format. Drs. Blankenbaker and Davis are proud of their newest book. “Donna and I agree that we work really well together on these projects, and it’s always a pleasure completing a textbook together,” says Dr. Davis. “We get a lot of satisfaction in seeing the completion of our hard work in print,” adds Dr. Blankenbaker.

Guang-Hong Chen, Fred Lee, and Jamey Weichert Receive Distinguished Investigator Awards

Guang-Hong Chen, PhD, Jamey Weichert, PhD, and Fred Lee, MD, were selected as recipients of The Academy for Radiology & Biomedical Imaging Research’s 2021 Distinguished Investigator Award. This award recognizes individuals for their outstanding contributions to the field of medical imaging. Drs. Chen, Lee, and Weichert were three of thirty-five award recipients. The honorees will be invited for formal induction into the Academy’s Council of Distinguished Investigators this fall during the 2021 Annual Meeting of the Radiological Society of North America (RSNA). “It’s a wonderful honor to be selected for the Distinguished Investigator Award by the Academy for Radiology and Biomedical Imaging, and [it] is a reflection of the environment for discovery that we have here at the University of Wisconsin and within the Department of Radiology,” said awardee Dr. Fred Lee. There are strict criteria that recipients must meet to receive the award, including at least twenty-five peer-reviewed scientific research publications in which the awardee is the first author or senior author and at least six years of funding as the Principal Investigator of a major competitive extramural research grant. Drs. Chen, Weichert, and Lee have each made significant contributions to radiology and medical imaging through their research.

Dr. Chen is the Director of the UW CT Lab, which aims to apply x-ray physics, innovative image reconstruction methods, and advanced computer technology to develop novel diagnostic tools for radiologists. “I am thrilled to receive this recognition and truly humbled to be nominated and elected to this class of distinguished investigators in medical imaging. This recognition is not an end point, but a new starting point for me and my research program to continue to develop new imaging techniques to facilitate clinical disease diagnoses and improve care to patients,” says Dr. Chen. Dr. Weichert is the Director of the Contrast Agent Lab, which is involved in the design, synthesis, and evaluation of novel targeted molecular imaging agents for computed tomography, magnetic resonance, and nuclear medicine including PET. “It is a great honor to be recognized by your peers,” says Dr. Weichert.

Dr. Lee started the Tumor Ablation Lab at UW. The goal of the lab is to develop minimally or non-invasive techniques to treat cancer, destroying malignant tissue while simultaneously minimizing damage to healthy tissue. “I came to UW as an Assistant Professor mostly focused on our clinical mission but interested in learning more about research. Over the ensuing years, I received tremendous support from our department and medical school who gave me the freedom and resources to pursue my research interests. The fact that I am one of multiple honorees shows that we have discovered the secret sauce here at UW, and as I look at our incredible junior faculty and trainees, I know that many will follow us in the forthcoming years,” says Dr. Lee. Congratulations to Drs. Chen, Weichert, and Lee on this wonderful achievement!

Medical Education Day 2021 Virtual Conference

On Thursday May 27^th, the UW-Madison School of Medicine and Public Health held the virtual Medical Education Day 2021 Conference. The conference is intended for healthcare professionals and staff across the state who teach in undergraduate medical education. A few members of the Department of Radiology presented at the conference. Associate Professor Jason Stephenson, MD and Professor Jonathan Swanson, MD held a workshop titled “Navigating the Winding Two-lane Highway: Tips to Improve the Giving and Receiving of Trainee Feedback.” The workshop used self-reflection, small group discussions, and case vignettes to improve how people give and receive feedback. In addition to the workshop, members of the Department gave presentations. Assistant Director of Education and Communications Katie Yang, MS gave a presentation titled “Personal Sustainability Practice - Integrating Practical Wellness Content into the Preclinical Curriculum of Medical School” which detailed the pilot of a wellness curriculum integrated into the course led by Yang and Dr. Stephenson. Assistant Professor Andrew Ross, MD, MPH gave his presentation on “A Remote Radiology Summer Research Mentoring Program for Medical Students” to discuss findings from the 2020 Radiology Shapiro Summer Research program. Dr. Stephenson provided an overview of his organizational content model for anatomy content in his presentation titled “The Suspension Bridge Model to Balance Content Volume, Learning Efficiency, and Cognitive Load.” Thank you to these faculty and staff members for representing the Department of Radiology so well at the conference!

SNMMII 2021 Annual Meeting Recap

The 2021 Society of Nuclear Medicine & Molecular Imaging (SNMMI) Annual Meeting was held virtually Friday, June 11^th – Tuesday, June 15^th. The SNMMI Annual Meeting is recognized as the premier educational, scientific, research, and networking event in nuclear medicine and molecular imaging. It provides physicians, technologists, pharmacists, laboratory professionals, and scientists with an in-depth view of the latest research and development in the field as well as providing insights into practical applications for the clinic. Many members of the Department of Radiology participated in and presented at the meeting. Read below to see the faculty, staff, and fellows who gave presentations during this year’s meeting. We are proud that UW was represented so well! Oral Presentations:

Vivek Prabhakaran, MD, PhD and Alan McMillan, PhD: PiB-PET Imaging of Post-Operative Delirium
Tyler Bradshaw, PhD and Steve Cho, MD: Evaluation of large language models in natural language processing of PET/CT free-text reports
Kelley Salem, PhD and Amy Fowler, MD, PhD: Progesterone receptor mediated regulation of 18F-fluorodeoxyglucose uptake in breast cancer
Petra Lovrec, MD; Tyler Bradshaw, PhD; Shane Wells, MD; Steve Cho, MD: PSMA-based 18F-DCFPyL PET/MRI for Prediction of Progression and Assessment of Response to Neo-Adjuvant Chemohormonal Therapy in Men with High-Risk Primary Prostate Cancer
Jonathan Ward Engle, PhD; Weibo Cai, PhD: ImmunoPET of CD146 in breast cancer metastatic models
Zachary T. Rosenkrans; Jeanine Batterton, PhD; Alan B. McMillan, PhD; Ali Pirasteh, MD, Reinier Hernandez:Targeting Activated Fibroblasts for non-invasive detection of Lung Fibrosis
Petra Lovrec, MD; Patrick Belson, MD; Shane Wells, MD; Steve Cho, MD; Metastatic Disease Response and Patterns of Recurrence in Men with High-Risk Prostate Cancer after Neo-Adjuvant Chemohormonal Therapy and Radical Prostatectomy utilizing PSMA-Targeted 18F-DCFPyL PET/CT
- Petra Lovrec, MD was awarded the SNMMI Early Career Professional - Clinical Track - 3rd place Abstract Winner for this presentation, along with winning 2^nd place in the Therapy Center of Excellence Young Investigator Awards.
Matthew G. Spangler-Bickell, PhD; Samuel A. Hurley, PhD; Ali Pirasteh, MD, Scott B. Perlman, MD, MS; Alan B. McMillan, PhD: Clinical Evaluation of Data-Driven Motion Corrected Reconstruction for PET Brain Imaging
Zachary Rosenkrans; Jonathan Ward Engle, PhD; Weibo Cai, PhD: Semiconducting polymers enhance Cerenkov radiation energy transfer for multimodal cancer theranostics
Kevin Fan; Weibo Cai, PhD: Comparison of 18F-FDG PET/MR and PET/CT in the diagnosis of neck recurrence or metastasis of differentiated thyroid cancer after operation
Steve Cho, MD: A Phase 3 study of 18F-DCFPyL-PET/CT in Patients with Biochemically Recurrent Prostate Cancer (CONDOR): An Analysis of Disease Detection Rate and Positive Predictive Value (PPV) by Anatomic Region

Faculty Spotlight: Prashant Nagpal

Associate Professor Prashant Nagpal, MD, FSCCT recently joined the Department of Radiology as the Chief of Cardiovascular Imaging. After working at the University of Iowa Hospital and Clinics, Dr. Nagpal is excited to be joining the faculty at UW. Learn more about him below. Q: Where are you from? A: I am originally from India but have spent my US life in Boston and Iowa City. Having spent most of my time in this part of the country, I like to call the Midwest my home. Q: Where did you attend Medical School? A: University College of Medical Sciences, University of Delhi, India. Q: Why did you choose Radiology? A: I realized very early in Medicine that Radiology is the key to making a majority of the diagnosis or arriving at next steps in patient management. And that is where I wanted to be. The technical advances in the field of cardiovascular imaging and their utilization for patient management excites me the most and drew me to the specialty. Q: What is your specialty? A: Cardiovascular and Thoracic Imaging. Q: What are your career interests and goals? A: To learn, improve and be a better version of myself – professionally and personally. I also hope to have a positive impact in the life of others. Q: Why did you choose UW/What are you excited about at UW? A: UW is an exciting place to work as it has great history of technical innovations and has physicians you feel proud to call your colleagues. There are resources and a system in place to pursue a path of clinical excellence and learning. Q: What are your hobbies? I love spending time with my family, play table-tennis (ping-pong), and I like to learn new technical / software skills like medical illustrations, video-making and editing.

AARS 2021 Recap

The 2021 ARRS (American Roentgen Ray Society) meeting took place virtually from April 18^th-22^nd. The meeting offered a wide variety of content, from instructional courses to scientific sessions to E-posters, all available on demand for a year for those who registered for the meeting. The UW Department of Radiology was well-represented at the meeting, with many faculty presenting during meeting courses (list of presentations below). Thank you to the faculty for representing UW! Presenters: Meghan Lubner, MD; Cholangiocarcinoma: Current Concepts; Biliary Imaging Course Kirkland Davis, MD, FACR; MR of the Painful Shoulder – beyond the labrum and cuff; MR Shoulder Update Course Perry Pickhardt, MD; Pitfalls in the GI Tract; Pitfalls in GI Imaging course Donna Blankenbaker, MD, FACR; Imaging of the athletic hip-intraarticular pathology; MR Imaging of the Hip and Pelvis Course Andrew Ross, MD, MPH; Ultrasound-Guided Nerve Intervention: A Guide For the Radiologist; Current Musculoskeletal Ultrasound: What Do I need to Know? Humberto Rosas, MD; Imaging of the post-operative meniscus; Imaging of the Post-Operative Knee Course Perry Pickhardt, MD; Quantitative and Automated CT Assessment for Diffuse Liver Disease; Gastrointestinal Imaging: Liver Course David Kim, MD, FACR; Rectal Cancer MRI Update; Gastrointestinal Imaging: Liver Course Maria Daniela Martin, MD; Imaging of Chest Trauma; Radiology Review: Chest Course Allison Grayev, MD; Spine Tumors & Mimics; CNS Tumors and Mimics Course Jonathan Swanson, MD; Imaging of the child with acute shortness of breath; Pediatric Chest and Body Radiology: Common Indications Course Tabby Kennedy, MD; Pearls and Pitfalls of the Skull Base; Radiology Review: Neuroradiology Course

AUR 2021 Recap

The 2021 Association of University Radiologists (AUR) annual meeting was held virtually from May 3^rd – May 6^th. The AUR annual meeting is an opportunity for people to share ideas and explore opportunities for collaboration with colleagues. The meeting held a variety of lectures, discussions, and poster events, all available on-demand for registrants until July 31^st, 2021. There were numerous UW faculty, staff, and students that participated in the meeting. We are proud to have the UW Department of Radiology well represented at these national conferences. Read below to learn more about UW participation in this esteemed event. E-Posters Patricia Krueger, BS; Andrew Ross, MD, MPH; Soterios Gyftopoulos, MD; and Sarah Daggett, BS co-authored Adherence to the STARD 2015 Reporting Guidelines for Studies of Diagnostic Accuracy in Musculoskeletal Radiology. The purpose of this study was to measure the adherence of diagnostic accuracy studies in musculoskeletal imaging with the Standards for Reporting Diagnostic Accuracy Studies (STARD) 2015 statement. Overall adherence of studies of diagnostic accuracy in musculoskeletal imaging to the STARD 2015 reporting guidelines is good, comparing favorably to other specialties. Steps for improvement include targeting radiologist education to low-adherence items and assessing journal editorial policies to improve the quality of reporting. Co-authors Patricia Krueger and Sarah Daggett are medical students who were both mentored by Dr. Ross during the 2020 Radiology Shapiro Summer Research Program (detailed in the poster below). Andrew Ross, MD, MPH; Katie Yang, MS; JP Yu, MD, PhD; Jason Stephenson, MD; and Tabby Kennedy, MD presented a poster titled A Remote Radiology Summer Research Mentoring Program for Medical Students. The purpose of this work was to examine the preservation of the benefits of early medical student summer radiology research through an innovative supplementary research mentoring program to increase engagement for remote learners during COVID-19. They concluded that providing additional virtual mentoring and resources to medical students completing remote summer research is perceived as helpful towards overall development; however, it does not necessarily increase student interest in pursuing Radiology. Andrew Ross, MD, MPH; Lindsay Stratchko, DO; Joseph Tang, MD; and Allison Grayev, MD co-authored the presentation titled Imaging Diagnosis and Radiology Directed Management of Pseudomeningoceles. Pseudomeningoceles are commonly encountered in radiology practice, and it is critical that radiologists can recognize this entity and suggest appropriate steps in diagnosis and management. This educational presentation provided a case-based review of pseudomeningoceles, including epidemiologic data and classification schema, clinical presentation and common iatrogenic etiologies, typical imaging features across multiple modalities, rare but important imaging variants, differential diagnosis and imaging features differentiating pseudomeningoceles from other fluid collections near the spine, radiology-directed diagnostic steps, and considerations for treatment. Katie Yang, MS, and Jason Stephenson, MD presented Radiology Discrepancy Reporting - Developing a System Useful for Patient Care and Education. Discrepancy rates between radiology resident preliminary on-call reports and final attending reports vary in the literature. While there are many potential causes of this discrepancy, the overall effect is ambiguity in reporting of the true prevalence or reporting

Spring 2021 Presentation Awards

Congratulations to the many Department of Radiology personnel who won awards at conferences this spring. We are proud to be so well-represented at these conferences by our esteemed faculty, staff, and students. Continue reading to learn more about some of the awards and honors that faculty members received this spring. Tabby Kennedy, MD, was awarded a Certificate of Merit by the American Society of Neuroradiology (ASNR) for her presentation, Head and Neck Manifestations of Systemic Disease. Dr. Kennedy was also featured in the RSNA article “Creative Approaches to Education Put Medical Students in the Driver’s Seat”. Howard Rowley, MD, was named a Fellow of the American College of Radiology (ACR). John Garrett, PhD, was placed in the Top 8 by the Society for Imaging Informatics in Medicine (SIIM) Machine Learning Committee for his model, Federated Learning AI Model for CXR Disease Classification Many faculty members received Certificates of Merit by the American Society of Neuroradiology (ASNR). Kelly Capel, MD; Anthony Kuner, MD; Oliver Wieben, PhD; Kevin Johnson, PhD; and Laura Eisenmenger, MD, received Certificates for their presentation, Beyond Time of Flight MRA: Review of Flow Imaging Techniques. Alexey Samsonov, PhD, joined Drs. Capel, Kuner, Johnson, and Eisenmenger for their presentation MRI Perfusion Techniques: Beyond Dynamic Susceptibility Contrast, which earned them their Certificates of Merit. At the 2021 International Society for Magnetic Resonance in Medicine (ISMRM) meeting, trainees of Department faculty members received awards for their presentations. Yavuz Muslu and Gregoy Simchick, mentored by Diego Hernandez, PhD, were awarded Summa Cum Laude Merit Awards. Nathan Roberts and Soudabeh Kargar, mentored by Scott Reeder, MD, PhD; Daniel Seiter and Ruiming Chen, mentored by Kevin Johnson, PhD; and Philip Corrado, mentored by Oliver Wieben, PhD, were all awarded Magna Cum Laude Merit Awards for their respective presentations.

2021 Zachary Clark Radiology Research Symposium Recap

The University of Wisconsin Department of Radiology annual research symposium is dedicated to the memory of Zachary Clark MS, MD. Dr. Clark completed his undergraduate degree at UW and a Masters at Northwestern before returning to UW-Madison for his Diagnostic Radiology Residency. He had a strong interest in neuroradiology research of cerebrovascular diseases and was in the Research Honors program within the residency. The Department of Radiology dedicates their annual resident research symposium to Dr. Zachary Clark, who truly embodied the concept of the clinician researcher. He is greatly missed by all. The research symposium was held virtually April 29^th and featured a number of fantastic presentations by UW radiology trainees. These presentations can be viewed via WebEx at this link. Continue reading to learn more about the exciting works at the symposium. Oral Presenters

Allison Couillard, MD; PGY2 Diagnostic Resident; Microwave ablation as bridging to liver transplantation for patients with hepatocellular carcinoma: a single-center retrospective analysis
Edward Lawrence, MD; Abdominal Imaging Fellow; Water-soluble contrast challenge for suspected small bowel obstruction
Nancy Ann Little, MD; PGY2 Diagnostic Resident; Effect of Metal Speculum During Hysterosalpingography on Patient Radiation Dose
Petra Lovrec, MD; Molecular Imaging/PET Fellow; Metastatic Disease Response and Patterns of Recurrence in Men with High-Risk Prostate Cancer after Neo-Adjuvant Chemohormonal Therapy and Radical
Albert Perez, MS4; Medical Student 4; Automated Deep Learning CT-based Liver Volume Segmentation: Defining Normal and Hepatomegaly for Clinical Practice
John Swietlik, MD; PGY6 IR-Integrated Resident; A model-based approach to histotripsy ablation target prediction using cone beam CT and fluoroscopy
Charles Viers, MD; PGY3 Diagnostic Resident; Transvaginal US vs. CT in Non-pregnant Premenopausal Women presenting to the ED: Clinical Impact of the Second Examination when Both are Performed
Andrew Wentland, MD, PhD; Abdominal Imaging Fellow; Differentiation of Benign from Malignant Pathology-Proven Solid Renal Lesions Using Radiomics and Machine Learning

Electronic Exhibits

Abdul Abdelazim, MD; Abdominal Imaging Fellow; Scientific Poster; Percutaneous microwave ablation of stage T1b RCC: A single center, retrospective study
Michael Bergquist, MD; PGY4 Diagnostic Fellow; ScientificPoster; From Clivus to Coccyx and anywhere in between, a case presentation of a mid-cervical chordoma; Longer term clinical outcomes of unilocular or multilocular cystic presacral lesions
Melissa Carroll, MD; Thoracic Imaging Fellow; Educational Exhibit; Intrathoracic Torsions: Twist and Shout
Mitchell Daun, MD; Musculoskeletal Imaging Fellow; Educational Exhibit; Imaging Diagnosis and Radiology Directed Management of Pseudomeningoceles