Charles Mistretta PhD

Professor Emeritus

Imaging Sciences

Picture of Charles Mistretta, PhD


Dr. Chuck Mistretta received his degree in High Energy Physics from Harvard University in 1968.
He has been doing research in medical imaging since 1971. His group was responsible for the
development of digital subtraction angiography (DSA) which was commercially introduced in 1980.
His research has focused on time resolved angiography and has resulted in the introduction of
accelerated imaging techniques such as TRICKS, VIPR and HYPR. Emphasis has been placed on the
development of accelerated MRI methods using sparse sampling which significantly violates the
traditional Nyquist sampling theorem, the use of non-Cartesian acquisition trajectories and the
application of constrained reconstruction techniques like HYPR and its derivatives.* Acceleration
factors as large as 1000 have been achieved in selected MRA applications. These techniques have
recently been extended to many areas of medical imaging such as PET, photoacoustic tomography and
X-ray CT where dose reductions of ten have been reported by several groups for perfusion studies.
Recently, fundamental mathematical advances by other groups have provided a firm explanation of
why these acceleration factors were possible.

Recently, Dr. Mistretta and Dr. Charles Strother introduced 4D DSA, an X-ray technique which adds
an additional dimension to traditional DSA by producing a time series of 3D image volumes at high
frame rates. Dr. Tom Grist, Chair of Radiology, describes Chuck as having had only two incredible
ideas in his whole career, and clarifies that they were both the same.

Dr. Mistretta is a Fellow of the AAPM, AIMBE, and ISMRM. He has received the Laufman Greatbatch Prize
for the development of DSA, and the J Allyn Taylor International Prize in Medicine. He was recently
the recipient of the 2010 Technology Achievement Award by the MIT Club of Wisconsin.

Dr. Mistretta has generated 33 issued US patents with 13 additional patents pending. He has mentored
33 Ph.D. students and 23 postdoctoral associates.

Dr. Mistretta’s priorities include family, fishing, golfing and music. Chuck plans to retire as soon
as elephants learn to fly.

* CA Mistretta, Undersampled Radial MR Acquisition and HYPR Reconstruction: Potential Medical Imaging
Applications in the Post Nyquist Era , JMRI, 29:501-516 (2009).