Charles Mistretta PhD

Professor Emeritus

Imaging Sciences

Picture of Charles Mistretta, PhD




    Dr. Chuck Mistretta received his degree in High Energy Physics from Harvard University in 1968.
    He has been doing research in medical imaging since 1971. His group was responsible for the
    development of digital subtraction angiography (DSA) which was commercially introduced in 1980.
    His research has focused on time resolved angiography and has resulted in the introduction of
    accelerated imaging techniques such as TRICKS, VIPR and HYPR. Emphasis has been placed on the
    development of accelerated MRI methods using sparse sampling which significantly violates the
    traditional Nyquist sampling theorem, the use of non-Cartesian acquisition trajectories and the
    application of constrained reconstruction techniques like HYPR and its derivatives.* Acceleration
    factors as large as 1000 have been achieved in selected MRA applications. These techniques have
    recently been extended to many areas of medical imaging such as PET, photoacoustic tomography and
    X-ray CT where dose reductions of ten have been reported by several groups for perfusion studies.
    Recently, fundamental mathematical advances by other groups have provided a firm explanation of
    why these acceleration factors were possible.

    Recently, Dr. Mistretta and Dr. Charles Strother introduced 4D DSA, an X-ray technique which adds
    an additional dimension to traditional DSA by producing a time series of 3D image volumes at high
    frame rates. Dr. Tom Grist, Chair of Radiology, describes Chuck as having had only two incredible
    ideas in his whole career, and clarifies that they were both the same.

    Dr. Mistretta is a Fellow of the AAPM, AIMBE, and ISMRM. He has received the Laufman Greatbatch Prize
    for the development of DSA, and the J Allyn Taylor International Prize in Medicine. He was recently
    the recipient of the 2010 Technology Achievement Award by the MIT Club of Wisconsin.

    Dr. Mistretta has generated 33 issued US patents with 13 additional patents pending. He has mentored
    33 Ph.D. students and 23 postdoctoral associates.

    Dr. Mistretta’s priorities include family, fishing, golfing and music. Chuck plans to retire as soon
    as elephants learn to fly.

    * CA Mistretta, Undersampled Radial MR Acquisition and HYPR Reconstruction: Potential Medical Imaging
    Applications in the Post Nyquist Era , JMRI, 29:501-516 (2009).